Since GraalPy tries to not lag behind CPython more than a year or so, we would be affected by this. Even if it might be considered a minor visible effect and/or an implementation detail, it is always surprising (to me) how much of those details end up being relied upon 
Because of details such as this we have recently switched to re-using the PEG parser and following the CPython bytecode compiler as closely as we possibly can, so I think that we would just pick up those same changes in observable behaviour without much headache.