Poblema Exception has occurred COMError (-2147200966, None

trato de solucionar pero no me sale

You tried to solve what? You haven’t given any details of what you were doing.

Have you installed pywin32?

py -m pip install pywin32

(The PyPI page for pyttsx3 says to install “pypiwin32”, but that’s very old and obsolete; install “pywin32” instead.)

After installing pywin32, did you also run the post-install script?

It’s explained here:

mhammond/pywin32: Python for Windows (pywin32) Extensions (github.com)