There is a lot of interest among Pyodide users in consuming asynchronous browser APIs from synchronous C / Python APIs. This is technically possible but requires some work to support. I think it would be good to get together some people from the community and try to organize work around this.
Alex Mojaki has some good work on this that I don’t fully understand:
I have my own synchronous RPC proof of concept:
As an example of one of the many cool features this work would enable, here is an example that wraps the chrome native filesystem API in a file system implementation.
It makes it possible to mount a directory from the user’s native OS into the Emscripten filesystem and then directly read and write to the file system from Pyodide.